Serotoninergic Systems in Anxiety
نویسنده
چکیده
Most work in the neurochemistry of anxiety has focused on the monoamines 5-HT and NA, the GABA-benzodiazepine (BDZ) receptor complex and a number of unrelated challenge compounds that are known to provoke anxiety and/or panic (e.g. cholecystokinin, sodium lactate, caffeine) . Interest in the GABAergic; 5-HTergic and NAergic systems originates from the clinical efficacy of compounds affecting these systems in the treatment of anxiety states and the study of their agonists and antagonists in the provocation and prevention of anxiety.
منابع مشابه
Corticosteroid-serotonin interactions in the neurobiological mechanisms of stress-related disorders.
Among psychiatric disorders, depression and generalized anxiety are probably the most common stress-related illnesses. These diseases are underlain, at least partly, by dysfunctions of neurotransmitters and neurohormones, especially within the serotoninergic (5-HT) system and the hypothalamo-pituitary-adrenal (HPA) axis, which are also the targets of drugs used for their treatment. This review ...
متن کاملاثر تجویز درونصفاقی عصاره هیدروالکلی و هگزانی گلهای حرارت دیده پایه ماده گیاه شاهدانه بر رفتار اضطرابی، تعادل و فعالیت حرکتی در موش صحرایی نر
Introduction: Decarboxylated phytocannabinoids activates CB1 receptors of endocannabinoid system in the central nervous system. Endocannabinoid system interacts with dopaminergic and serotoninergic systems, which seems to be effective on the behavior processes. Therefore, this study aimed to investigate the effect of hydroalcoholic and hexanic extract of heated female Cannabis sativa flowertops...
متن کاملVenlafaxine - quetiapine combination in the treatment of complicated clinical picture of enduring personality changes following PTSD in comorbidity with psychotic depression.
PTSD is a complex disorder, which frequently occurs in comorbidity with anxious disorder, personality disorder, addiction or substance abuse disorder, depressive disorder with or without psychotic symptoms and psychotic disorder. PTSD symptoms may result from deregulation of several different neurotransmitter systems. Pharmacotherapy of PTSD depends on clinical features and the presence of como...
متن کاملGABAergic and Serotoninergic systems on Hypothalamic Catecholamines
OBJECTIVES: The aim of the present investigation was to determine whether the catecholaminergic system is involved in gabaergic and serotoninergic effects on gonadotrophin secretion during sexual development. To this end, we studied the effect of GABAergic and serotoninergic systems on hypothalamic catecholamine content at different stages of sexual development. METHODS: The effect of GABA A an...
متن کامل[Attention deficit hyperactivity disorder (ADHD): an overview].
Attention Deficit Hyperactivity Disorder (ADHD) is a common disorder in children and it has been increasingly diagnosed in adults, as well. The prevalence in adults is reported to be between 4-5%. It is estimated that between 50-70% of all children suffering ADHD maintain the condition into their adulthood. There are several criteria used for the detection and diagnosis of ADHD, which are descr...
متن کامل